5.08J / 7.08J Biological Chemistry II

As taught in: Spring 2004

Structural image of protein complex from PDB database.

The Structure Of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase I In Complex With Thiolactomycin, Implications For Drug Design. PDB ID: 1FJ4.  Price, A. C., Choi, K., Heath, R. J., Li, Z., White, S. W., Rock, C. O.: Inhibition of Beta-Ketoacyl-[Acyl Carrier Protein] Synthases by Thiolactomycin and Cerulenin: Structure and Mechanism J.Biol.Chem. 276 pp. 6551 (2001). (Image courtesy of the Research Collaboratory for Structural Bioinformatics.  H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne The Protein Data Bank. Nucleic Acids Research, 28 pp. 235-242 (2000).)




Prof. Joanne Stubbe

Prof. Alice Ting

Course Features

Course Highlights

The tools section includes information about various molecular graphics programs used to view three-dimensional structures in this course.

Course Description

This course deals with a more advanced treatment of the biochemical mechanisms that underlie biological processes. Emphasis will be given to the experimental methods used to unravel how these processes fit into the cellular context as well as the coordinated regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and the structure and function of nucleic acids.

Technical Requirements

Special software is required to use some of the files in this course: .pdb and .spt.

*Some translations represent previous versions of courses.